About 1 result found for searched term "Resmetirom (MGL-3196)" (0.237 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3184 | Resmetirom (MGL-3196) | Thyroid Hormone Receptor |
| VIA-3196; MGL-3196 | ||
| Resmetirom (MGL-3196, VIA-3196, resmetirom) is a potentially first-in-class, liver-targeted, orally active, selective thyroid hormone receptor (THR)-β agonist with an EC50 value of 0.21 μM. Resmetirom avoids the activation of THR-α receptors that mediate thyroid hormone activity outside of the liver, including the heart and bone. Resmetirom avoids the activation of THR-α receptors that mediate extrahepatic (including cardiac and skeletal) thyroid hormone activity and can be used in studies of non-alcoholic steatohepatitis (NASH). | ||
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